In Vitro Permeation Testing (IVPT), or skin permeation testing, is a critical tool for evaluating drug delivery into the various layers of skin as part of the formulation selection formulated for topical and transdermal application.

In vitro assessment of topical (dermal) and transdermal pharmacokinetics is a critical aspect of the drug development process for semi-solid products (e.g., solutions, foams, sprays, creams, gels, lotions, ointments), allowing for informed selection of new chemical entities, optimization of prototype formulations during the nonclinical stage, and determination of bioequivalence of generics. It can also serve as a tool to further understand the impact of different excipients on drug delivery, product quality, and formulation microstructure when used in parallel with other techniques, such as analyses of rheology, viscosity, microscopic characteristics, release rate, particle size, and oil droplet size distribution. Successful execution of the IVPT also involves the development and use of fit-for-purpose bioanalytical methods and procedures.

VitelyBio can help you identify actives with optimal penetration properties, characterize the active ingredients skin distribution and quantify drug formulations that deliver the drug to the target layer of the skin.